Identification of meningioma recurrence gene expression signature by DNA microarray experiments
نویسندگان
چکیده
Meningioma recurrence after complete removal remains one of the most relevant problems of meningioma treatment. DNA microarray technologies allow the screening of several thousands genes simultaneously. This gene expression profiling approach has been successfully applied in many researches associated with tumor classification. We analyzed genome wide expression profiles of 68 meningioma samples. The differential gene expression analysis was conducted to identify meningioma recurrence gene expression signature. The gene set enrichment analysis and Cox proportion hazards methods were used to characterize the gene signature. A total of 99 genes (65 up and 34 down) were identified as significantly regulated in recurrent meningioma tumors. These genes mainly enriched in the biological process of cell cycle. Among them, seven genes were significantly associated with meningioma patients’ overall survival. The cell cycle genes may play a vital role in the meningioma progression. However, further research is required to validate our findings and discover novel treatment and prognosis potentialities.
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